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Newly Uncovered Cause and Treatment for Common High Blood Pressure Type

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Researchers at Queen Mary University of London have identified a gene variant responsible for a type of hypertension present in 5% of affected individuals. This variant contributes to benign nodules that excessively produce aldosterone, a hormone regulating sodium and potassium levels, leading to high blood pressure. The study emphasizes that a 24-hour urine test for aldosterone could enhance diagnosis and treatment, as traditional one-off blood tests are often insufficient.

The condition can be effectively cured through unilateral adrenalectomy, which involves removing one adrenal gland. Post-surgery, patients previously resistant to multiple antihypertensive medications experienced normalization of blood pressure without ongoing treatment. The research highlights that fewer than 1% of aldosterone-related hypertension cases are diagnosed due to inadequate hormone measurement practices.

The gene variant affects the CADM1 protein, disrupting cellular communication and causing intermittent aldosterone overproduction. This fluctuation complicates diagnosis, making it crucial for clinicians to perform tests at various times throughout the day. The study illustrates the interconnectedness of scientific research and clinical practice, with ongoing investigations exploring minimally invasive options for treating these nodules. Funding for this research came from several esteemed organizations, further underscoring its significance.

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