Research at the Beckman Institute for Advanced Science and Technology reveals that exercise can directly enhance brain health, particularly by fostering neuronal development in the hippocampus, a crucial area for learning and memory. The study focuses on the chemical signals released by contracting muscle cells, which promote growth and organization in brain networks. When muscles contract, they secrete various compounds into the bloodstream that travel to the brain, positively affecting hippocampal neurons.
Lead author Ki Yun Lee explains that understanding this connection can lead to exercise-based treatments for cognitive disorders like Alzheimer’s disease. The researchers grew muscle cells from mice and observed how their chemical signals affected hippocampal neurons in cell cultures. The results demonstrated that these signals increased neuronal activity and promoted synchronized electrical firing, indicating healthier and more organized neuron networks.
Astrocytes, star-shaped glial cells in the brain, play a mediating role in this process. The study found that removing astrocytes led to heightened neuronal activity, suggesting these cells are vital for regulating neuronal responses. Ultimately, this research aims to unlock more effective exercise regimens for improving cognitive function and tackling disorders associated with brain health.
