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Do Osteoarthritis Treatments Really Work? A New Study Challenges Their Effectiveness

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Osteoarthritis is a prevalent degenerative joint disease primarily impacting cartilage, characterized by joint pain, stiffness, and reduced mobility. Its prevalence increases with age, affecting about one million adults over 45 in Sweden. A research team from Lund University highlights the challenges in clinical studies related to osteoarthritis, particularly regarding pain variability in patients. They emphasize that selecting individuals experiencing high pain levels may skew research results due to "regression to the mean," a phenomenon where those with extreme pain tend to show less pain over time, regardless of treatment. This can lead to the false impression that treatments are effective, as observed improvements may stem from normal pain fluctuations rather than actual therapeutic impact.

Using data from a U.S. population-based study, researchers found that regression to the mean accounted for about one point on a pain scale, which is significant given that average pain reductions in studies usually range from 1 to 2.5 points. Consequently, robust clinical trials must include control groups, randomized treatments, and blinded participants to assess treatment efficacy accurately. The study, published in The Lancet Rheumatology, calls for rigorous evaluation of osteoarthritis treatments to prevent overstatements of efficacy for emerging therapies.

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