Researchers at UC San Diego have engineered a biosynthetic genetic ‘clock’ that significantly extends cellular lifespan, as reported in the journal Science. By reprogramming the gene regulatory circuit controlling cell aging into a clock-like oscillator, they enable cells to switch between two detrimental aged states, thereby reducing degeneration. This innovative approach, demonstrated in yeast cells, resulted in an impressive 82% increase in lifespan compared to control cells.
The study builds on previous research identifying two distinct aging pathways in cells, leading to the development of a mechanism to prevent deterioration typically associated with aging. The engineered circuit operates as a negative feedback loop, effectively staving off the aging process. Employing computational simulations to guide their synthetic biology efforts has been key to their success.
According to Professor Nan Hao, the approach could reshape strategies for delaying aging by maintaining a flexible aging process instead of reverting cells to an artificial youthful state. The team plans to further explore aging mechanisms in human cells, potentially revolutionizing treatments for aging-related diseases. Their findings underscore a strong link between gene network architecture and cellular longevity, paving the way for future longevity-enhancing interventions.
