A recent study found that reduced oxygen intake, or “oxygen restriction,” may significantly extend lifespan in lab mice. Researchers observed that mice bred for accelerated aging lived approximately 50% longer in an oxygen-restricted environment (11% oxygen, akin to conditions at 5,000 meters altitude) compared to those in normal oxygen (21%). This finding suggests a novel anti-aging strategy that differs from traditional methods like dietary restriction, as the improved lifespan was not linked to changes in food intake. The oxygen-restricted mice demonstrated a median lifespan of 23.6 weeks, versus 15.7 weeks for mice in standard oxygen levels, and also showed delayed aging-related neurological decline.
This study, led by Robert Rogers of Massachusetts General Hospital, is pioneering in demonstrating that oxygen restriction positively affects mammalian lifespan. While previous research had indicated similar benefits in other organisms like yeast and fruit flies, this marks the first evidence in mammals. The researchers stress the need for further investigation to uncover the molecular mechanisms involved and explore potential implications for human longevity. Overall, these findings open new avenues for anti-aging research and highlight the possible benefits of oxygen restriction for extending healthy life spans.
