Recent research from the University of Lausanne suggests that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, offering a potential pathway to counteract age-related tissue degeneration. Published in eLife, the study highlights the decline in osteoprogenitor cells—essential for bone tissue creation—as animals age, particularly impacting calvarial bones. The researchers found that aging resulted in decreased bone structure, healing capacity, and mitochondrial function in these cells, leading to impaired regeneration.
To address these issues, the team utilized a Wnt3a delivery bandage to boost osteoprogenitor numbers, but healing did not improve significantly until they introduced intermittent fasting. This dietary approach increased mitochondrial activity and reduced cellular stress, leading to bone repair levels similar to those seen in younger mice. Additionally, fasting influenced gut microbiome health, specifically increasing the beneficial bacterium Akkermansia muciniphila, further enhancing tissue repair. Although promising, the study’s findings require further validation in humans to potentially lead to therapeutic strategies for improved bone healing and overall tissue function in older adults.
