Vitamin B6 is vital for brain function, with deficiencies linked to memory issues and depression. However, simply taking supplements is not enough to combat these disorders. Researchers at Würzburg University Medicine have found a promising approach by inhibiting the degradation enzyme pyridoxal phosphatase, which can increase cellular B6 levels. This inhibition was shown to enhance brain functions and offers potential treatment options for mental and neurodegenerative disorders.
Low vitamin B6 levels are associated with cognitive decline, memory impairment, and various mental health issues, particularly in the elderly. Previous studies suggested increasing B6 intake, yet the precise role of the vitamin in mental illness remains unclear. The researchers discovered that the natural compound 7,8-Dihydroxyflavone can inhibit pyridoxal phosphatase, effectively slowing down the degradation of B6 and improving learning and memory in studies.
The findings, published in eLife, highlight the potential of drug development targeting this enzyme, although much work remains to create effective inhibitors for clinical applications. Future research aims to explore the combined use of vitamin B6 and pyridoxal phosphatase inhibitors for treating mental and neurodegenerative disorders.
