Researchers at Monash University’s Australian Regenerative Medicine Institute have found that, as both humans and the African killifish age, their muscles can revert to an “early-life” state, potentially extending lifespan. This study, led by Professor Peter Currie and Dr. Avnika Ruparelia, focused on the African killifish due to its short lifespan and aging symptoms akin to those in humans. Muscle degradation, known as sarcopenia, is a major aspect of aging, and the study reveals that muscle health can actually improve in late life, countering deterioration.
Examining the killifish’s metabolism, the researchers discovered that older fish exhibited some rejuvenated metabolic features resembling those of younger fish. This rejuvenation is linked to lipid metabolism, suggesting manipulation of cell metabolism could help mitigate muscle aging. The study proposes that a state akin to calorie restriction, common among long-living organisms, may activate mechanisms that promote nutrient balance and longevity.
These findings offer promising insights into combating sarcopenia and its implications, which are increasingly significant given the aging global population. The researchers emphasized the potential to develop therapeutics aimed at supporting healthy muscle aging, marking a significant advancement in regenerative medicine.
